CHEM 1340La, General Chemistry Laboratory I  Jonathan Parr

An introduction to basic chemistry laboratory methods. Techniques required for quantitative analysis of thermodynamic processes and the properties of gases. To accompany or follow CHEM 161 or 163. May not be taken after a higher-numbered laboratory course.  SC  RP  0 Course cr
HTBA

CHEM 1360La, General Chemistry Laboratory II  Laura Herder

Introduction to rate and equilibrium measurements, acid-base chemistry, synthesis of inorganic compounds, and qualitative/quantitative analysis. After CHEM 134L or the equivalent in advanced placement. To accompany or follow CHEM 165 or 167. May not be taken after a higher-numbered laboratory course.  SC  RP  0 Course cr
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* CHEM 1610a or b, General Chemistry I  Staff

A comprehensive survey of modern descriptive, inorganic, and physical chemistry. Atomic theory, stoichiometry, thermochemistry, chemical periodicity, concepts in chemical bonding, and the shapes of molecules. Appropriate either as a first chemistry course or for students with one year of high school chemistry. Attendance at a weekly discussion section required. Normally accompanied by CHEM 134L.  QR, SC  RP  0 Course cr
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* CHEM 1650a or b, General Chemistry II  Staff

Topics include kinetics, chemical equilibrium, acid-base chemistry, free energy and entropy, electrochemistry, and nuclear chemistry. Attendance at a weekly discussion section required. Prerequisite: CHEM 161. Normally accompanied by CHEM 136L. Enrollment by placement only.  QR, SC  RP  0 Course cr
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* CHEM 1700a, Quantitative Foundations of General Chemistry  Patrick Holland

An advanced course emphasizing conceptual aspects and physical principles in general chemistry. Fulfills the general chemistry prerequisite for organic chemistry. Attendance at a weekly discussion section required. Enrollment by placement only.  QR, SC  0 Course cr
MWF 10:30am-11:20am

* CHEM 1710La, Quantitative Foundations of General Chemistry Lab  Laura Herder

This laboratory affords students at the beginning of their science studies to have meaningful and foundational engagement with experimental chemistry. The lab equips students for further science laboratory classes and laboratory research in the sciences. The course is structured to take students with little or no prior exposure to practical work in the sciences through a series of experiments in which they use scientific apparatus and practice techniques that are core to experimental work in chemistry and other physical sciences. This includes experiments involving calorimetry, electrochemistry, volumetric analysis, computational chemistry, spectroscopy, and synthesis. Students finish with a strong grounding in laboratory safety and experimental design, as well as in the collection and recording of measured and observational data, in addition to exposure to the apparatus and software platforms common to many physical science laboratories. This lab qualifies students for the organic chemistry laboratory sequence (CHEM 222L/223L). Prerequisites: By course placement. This laboratory class is intended to accompany CHEM 1700 only and may not be taken by any student unless they are either enrolled in CHEM 1700 concurrently or have already completed CHEM 1700 and have not in either case completed a higher numbered Chemistry laboratory class,  SC  0 Course cr
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* CHEM 1740a, Organic Chemistry for First Year Students I  Jon Ellman

An introductory course focused on current theories of structure and mechanism in organic chemistry, their development, and their basis in experimental observation. Open to first-year students with excellent preparation in chemistry, mathematics, and physics who have taken the department's advanced chemistry placement examination. Attendance at a weekly discussion section required. Normally accompanied by CHEM 222L. Enrollment by placement only.  SC  RP  0 Course cr
MW 9am-10:15am

* CHEM 1750b, Organic Chemistry for First Year Students II  David Spiegel

Continuation of CHEM 174. Survey of simple and complex reaction mechanisms, spectroscopy, organic synthesis, and the molecules of nature. Attendance at a weekly discussion section required. After CHEM 174. Normally accompanied by CHEM 223L. Enrollment by placement only.  SC  RP  0 Course cr
MW 9am-10:15am

CHEM 2200a or b, Organic Chemistry  Staff

An introductory course covering the fundamental principles of organic chemistry. The laboratory for this course is CHEM 222L. After college-level general chemistry. Students who have earned a grade lower than C in general chemistry are cautioned that they may not be sufficiently prepared for this course. Usually followed by CHEM 221 or 230.  SC  RP  0 Course cr
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CHEM 2210b, The Organic Chemistry of Life Processes  Scott Miller

The principles of organic reactivity and how they form the basis for biological processes. The laboratory for this course is CHEM 223L. After CHEM 220. Students who have earned a grade lower than C in CHEM 220 are cautioned that they may not be sufficiently prepared for this course.  SC  RP  0 Course cr
MW 9am-10:15am

CHEM 2220La or b, Laboratory for Organic Chemistry I  Christine DiMeglio

First term of an introductory laboratory sequence covering basic synthetic and analytic techniques in organic chemistry. Prerequisite: CHEM 136L or equivalent. After or concurrently with CHEM 174 or 220.  SC  0 Course cr
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CHEM 2230Lb, Laboratory for Organic Chemistry II  Christine DiMeglio

Second term of an introductory laboratory sequence covering basic synthetic and analytic techniques in organic chemistry. Prerequisite: CHEM 222L. After or concurrently with CHEM 175, 221, or 230.  SC  0 Course cr
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* CHEM 2260La, Advanced Chemistry Lab  Christine DiMeglio

An advanced course in chemistry laboratory technique intended to develop student independence and confidence with planning and executing experimental procedures, while performing synthetic and analytical experiments.  The course includes workshops, interactions with specialists in instrumentation, library science, and safety, an individual project, and training in the use of various instrumentation and techniques. Students must have received a grade for General Chemistry Lab I and II (CHEM 134L and 136L), or their equivalents, such as a college course elsewhere or the Chemistry Department placement exam. Organic Chemistry Lecture I and II (CHEM 220 and 221) and Organic Chemistry Labs I and II (CHEM 222L and CHEM 223L), or their equivalents are also pre-requisites. Enrollment is limited; capped to 7 people. Please e-mail course instructor to be put on a waitlist if cap is reached.  WR, SC  RP
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CHEM 2520b, Introductory Inorganic Chemistry  Nilay Hazari

Principles and applications of modern inorganic chemistry. Introduction to some of the fundamental concepts of solid-state chemistry, coordination chemistry, bioinorganic chemistry, and organometallic chemistry. Prerequisite: college-level general chemistry. After or concurrently with CHEM 220 or by permission of instructor. May not be taken after CHEM 450, 452, or 457.  SC  RP  0 Course cr
MWF 10:30am-11:20am

CHEM 3190b, Chemical Biology: Chemical Dissection & Reprogramming of Biological Systems  Jason Crawford

This course is organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures, including core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis. Prerequisites: CHEM 220 and CHEM 221.  SC  0 Course cr
TTh 9am-10:15am

CHEM 3300La, Laboratory for Physical Chemistry I  Paul Cooper

Introduction to the tools and techniques of modern experimental physical chemistry, including analog/digital electronics, quantitative measurements of basic thermodynamic properties, and nuclear magnetic resonance spectrometry. After or concurrently with CHEM 328 or 332.   SC  RP  0 Course cr
F 1:30pm-2:20pm

* CHEM 3320a, Physical Chemistry with Applications in the Physical Sciences I  Staff

CHEM 332 is an introductory course to fundamentals of physical chemistry, with an emphasis on macroscopic phenomena in chemical, physical, and biological systems. This course covers topics including fundamental laws of thermodynamics, properties of gases, phase equilibrium and transition, properties of solutions, chemical equilibrium, and chemical kinetics. This course, together with CHEM 333, provides a foundation for understanding the connection between chemistry and physics as well as theoretical chemistry. Prerequisites: introductory physics (PHYS 1700, 1800, or higher), college-level general chemistry (CHEM 1610/1650, or CHEM 1700, and/or CHEM 163/167), and single-variable calculus (Math 1150, 1160, or upper-level MATH equivalents), all taken for a grade. The MATH prerequisite may be fulfilled by taking the placement exam offered by the mathematics department and providing documentation of placement into a course beyond MATH 1150 or by providing evidence of transfer credit for an equivalent course completed (for letter grade) at another institution. Both of the latter options must be approved by the DUS. May not be taken after CHEM 3280.  QR, SC  RP  0 Course cr
MWF 9:25am-10:15am

* CHEM 3330b, Physical Chemistry with Applications in the Physical Sciences II  Eric Arsenault

Continuation of CHEM 332, including topics drawn from quantum mechanics, atomic/molecular structure, spectroscopy, and statistical thermodynamics. Prerequisite: CHEM 328 or 332, or permission of instructor.   QR, SC  RP  0 Course cr
MWF 9:25am-10:15am

* CHEM 4000a, Current Chemistry Seminar  Ruth Son

Designed to engage students in the Chemistry research-seminar program by providing requisite scientific guidance and a forum for directed discussion. Participants explore current avenues of chemical research as presented orally by the prime movers in the field, thereby exploring the frontiers of current knowledge while still retaining the structured environment of a classroom. May fulfill all or part of the senior requirement for the Chemistry major, as detailed in the program description in the YCPS.
F 11:30am-1pm

CHEM 4020a, Fundamentals of Transition Metal Chemistry  James Mayer

This half-term course covers the structures and properties of coordination compounds, and strategies for the design and analysis of new compounds. Elements of chelating ligands, spectroscopic methods, and magnetism are addressed. Prerequisites: Two terms of organic chemistry, and Chem 252 or equivalent.  SC  ½ Course cr
TTh 9am-10:15am

CHEM 4030a or b, Fundamentals of Organometallic Chemistry  Staff

A half-term survey of the main principles of organometallic chemistry that enable students to understand basic concepts in the field. It prepares students for CHEM 404, Applications of Organometallic Chemistry, the second half of this course. Prerequisites: Two terms of organic chemistry and Chem 252 or equivalent experience.  SC  ½ Course cr
MW 11:35am-12:50pm

CHEM 4060a, Bioinorganic Spectroscopy  Gary Brudvig

This course is an advanced introduction to biological inorganic chemistry with an emphasis on the methods used to characterize the active sites of metalloproteins. The major physical methods used in the determination of molecular structure, bonding and physical properties of metal ions in proteins are introduced.  Prerequisite: A general knowledge of biochemistry and familiarity with both inorganic coordination chemistry and physical chemistry.  SC  ½ Course cr
MW 11:35am-12:50pm

CHEM 4070a, Bioinorganic Mechanisms  Gary Brudvig

This course is an advanced introduction to biological inorganic chemistry. An overview of the relevant geometric and electronic structures of metalloprotein active sites are presented and related to each protein’s function. The objective is to define and understand the function of metals in biology in terms of structure. Prerequisite: CHEM 406 or permission of instructor. It will be assumed that students have a general knowledge of biochemistry and are familiar with both inorganic coordination chemistry and physical chemistry.   SC  ½ Course cr
MW 11:35am-12:50pm

CHEM 4080a, Principles of Materials Chemistry  Hailiang Wang

This course is an advanced introduction to materials chemistry. It aims to serve senior undergraduate students who are interested in learning and applying chemical principles for materials research and applications. Fundamental principles in solid-state chemistry, including crystal structures and chemical interactions, will be taught. Ionics, metal, semiconductor and polymer materials, including their synthesis, structures, properties and applications, will be discussed. Prerequisite: General chemistry, inorganic chemistry and physical chemistry, or equivalent experience.  SC  ½ Course cr
MW 9am-10:15am

CHEM 4160a, Organic Structure and Energetics  William Jorgensen

The course covers concepts in physical organic chemistry including molecular structure & bonding, conformational energetics, electronic effects, thermochemistry, ring strain, non-covalent interactions, molecular recognition, and host-guest chemistry. Prerequisites: Two terms of organic chemistry and two terms of physical chemistry or related courses or permission of the instructor.  SC  ½ Course cr
TTh 11:35am-12:50pm

CHEM 4170a, Kinetics and Thermodynamics in Organic Systems  William Jorgensen

The course generally follows Organic Structure and Energetics. This module covers concepts in physical organic chemistry including acid-base chemistry, advanced issues in stereochemistry, kinetics and thermodynamics, as well as experiments and techniques employed in mechanistic analysis. Issues in catalysis are addressed throughout. Prerequisites: CHEM 416 and two terms of introductory organic chemistry, and two terms of physical chemistry. Permission of the instructor may be sought for potential exceptions.  SC  ½ Course cr
TTh 11:35am-12:50pm

CHEM 4190a, Proteomics and Chemical Glycobiology  Stacy Malaker

Chemical biology deals with how chemistry can be applied to manipulate and study biological problems using techniques from organic chemistry, analytical chemistry, biochemistry, molecular biology, biophysical chemistry, and cell biology. This course covers topics related to the structure of proteins and oligosaccharides, protein engineering and labeling, and glycosylated proteins/nucleic acids. These play important roles throughout biochemistry and human health. Prerequisites: Two terms of both General Chemistry I and II (CHEM 161/165 and/or CHEM 163/167) as well as Organic Chemistry (CHEM 174/175 and/or CHEM 220/221).  SC  ½ Course cr
TTh 9am-10:15am

CHEM 4210a, Protein Design & Catalysis  Jason Crawford

The lecture component of this course largely focuses on protein function, catalysis, and the chemistry and biology of diverse small molecule products. The course also serves to support students in writing an effective NSF style research proposal in Chemical Biology and communicating its contents to a diverse scientific audience.  PREREQUISITES: Two semesters of undergraduate organic chemistry (CHEM 1740/1750 and/or CHEM 2200/2210). One semester of Chemical Biology: Chemical Dissection & Reprogramming of Biological Systems (CHEM 3190). A basic understanding of biochemistry and molecular biology is also assumed, but you can “catch up” by carefully and thoroughly reading the course materials and recommended books.  SC  ½ Course cr
TTh 9am-10:15am

CHEM 4320b, Synthetic Methods in Organic Chemistry I  Seth Herzon

Compound synthesis is essential to the discovery and development of new chemical entities with a desired property whether that be for fundamental study or for a more applied goal such as a new pharmaceutical, agrochemical, or material. In this course we emphasize key transformations and principles to provide a framework for the efficient design and synthesis of organic compounds. Prerequisites: Two terms of organic chemistry and one term of introductory inorganic chemistry, or related course, or permission of the instructor.  SC  ½ Course cr
MW 11:35am-12:50pm

CHEM 4330b, Synthetic Methods in Organic Chemistry II  Jon Ellman

Compound synthesis is essential to the discovery and development of new chemical entities with a desired property whether that be for fundamental study or for a more applied goal such as a new pharmaceutical, agrochemical, or material. In this course we emphasize key transformations and principles to provide a framework for the efficient design and synthesis of organic compounds. This course builds on the knowledge learned in CHEM 432. Prerequisite: CHEM 432 or permission of instructor.  SC  ½ Course cr
MW 11:35am-12:50pm

CHEM 4780a, Molecules and Radiation I  Kurt Zilm

This course is an efficient entry to the study of molecular spectroscopy and provides a broad foundation for chemical physicists, biophysicists, and engineers. It covers a general treatment of the quantum mechanics of spectroscopy and specific applications for time-dependent systems. This course focuses on matrix mechanics, perturbation theory, and angular momentum. Prerequisite: previous exposure to quantum mechanics at the level of physical chemistry, or permission of the instructor. There will be a brief review of some of this material in class.   SC  ½ Course cr
MWF 9:25am-10:15am

CHEM 4790a, Molecules and Radiation II  Kurt Zilm

This course is a continuation and builds on the foundation of quantum mechanics learned in CHEM 4780/5780. During CHEM 4790/5790, the curriculum will continue with group theory, time-dependent quantum mechanics and end with applications to coherent optical and magnetic resonance. This course was designed recognizing that most of the quantum needed to understand modern spectroscopy, and is a very useful foundation for other magnetic resonance and optical spectroscopy courses offered by the Department. CHEM 4780 or permission of the instructor  SC  ½ Course cr
MWF 9:25am-10:15am

* CHEM 4800a, Introduction to Independent Research in Chemistry  Sarah Slavoff

After consultation with the DUS, students engage individual experimental and/or theoretical research problems in the laboratories of a selected faculty member within the Chemistry department. At the end of the term, students submit a brief report summarizing goals, methods, and accomplishments. For each term of enrollment, students must complete the CHEM 480 registration form, available in the DUS office, and have it signed by their faculty research mentor. It must be submitted to the Chemistry DUS for final approval no later than the last week of classes in the immediately preceding academic term. Individuals wishing to perform independent research must have demonstrated proficiency in the aspects of chemistry required for the planned project, as ascertained by the supervising faculty member, and must meet basic safety requirements prior to undertaking any activities, including certified completion of the online courses entitled Laboratory Chemical Training and Hazardous Chemical Waste Training administered by the Office of Environmental Health and Safety (EHS) at http://ehs.yale.edu/training. At least ten hours per week of research are required (including time spent on requisite safety training), with the faculty mentor affirming this level of student commitment by midterm. This course may be taken multiple times for Pass/Fail credit, subject to restrictions imposed by Yale College.  RP
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* CHEM 4900a, Independent Research in Chemistry  Jonathan Parr

Senior Chemistry majors engage individual experimental and/or theoretical research problems in the laboratories of a selected faculty member in the Chemistry department or in a closely related field of molecular science. CHEM 490 registration forms, found in the DUS office, must be signed by the student’s faculty research mentor and submitted it to the Chemistry DUS for final approval no later than the last week of classes in the immediately preceding academic term. Mandatory class meetings address issues of essential laboratory safety and ethics in science, with other class sessions focusing on core topics of broad interest to Chemistry students, including online literary research, oral presentation skills, and effective scientific writing. At least ten hours of research are required per week. Students are assigned letter grades, subject to restrictions imposed by Yale College. In special cases and with DUS approval, juniors may take this course.   RP
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CHEM 4920a, Biochemical Rates and Mechanisms I  J Patrick Loria

An advanced treatment of enzymology. Topics include transition state theory and derivation of steady-state and pre-steady-state rate equations. The role of entropy and enthalpy in accelerating chemical reactions is considered, along with modern methods for the study of enzyme chemistry. These topics are supplemented with in-depth analysis of the primary literature Prerequisites: CHEM 332 or equivalent, two semesters of organic chemistry, Math 115.  SC  ½ Course cr
MW 11:35am-12:50pm